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St John's wort (Hypericum perforatum)

Helps relieve stress, mild anxiety and symptoms of mild to moderate depression

St. John’s wort is well-studied and recommended worldwide for helping to relieve mild anxiety and symptoms of mild to moderate depression. 1

Research Specific extract

Hypericum perforatum, commonly known as St. John’s wort, has long been recognised for its medicinal health benefits since Ancient Greece. Today St. John’s wort is well-studied and recommended worldwide for helping to relieve mild anxiety and stress.1

 

Because of this, there are many types of St. John’s wort preparations in the form of teas, tinctures, liquids, powders, tablets, and capsules. These are often made with varying production methods, which can result in different amounts of active components.

 

In Remotiv® a specific extract of Hypericum perforatum – called Ze 117 – is used. Remotiv with Ze 117 has been extensively researched in clinical studies and is used by millions worldwide to support a healthy mood.

 

Discover more about Ze 117 used in Remotiv and the key studies that support its benefits.

Hypericum perforatum in history

Hypericum perforatum, commonly known as St. John’s wort, is a commonly used herb for relief of stress, mild anxiety and mood-related symptoms. St. John’s wort is native to Europe, North Africa and western Asia.1

The value of St. John’s wort has been known for over 2000 years. Greek medical herbalists, such as Hippocrates, Galen and Dioscoridies historically used this herb in various applications relating to nerve complaints.1

 

St. John’s wort continued to be used through the Middle Ages, however in the early 1500s, it was Paracelsus that exposed its benefits in supporting healthy mood and emotional balance.1 In the following centuries the use of St. John’s wort spread across Europe and other continents and became more widely used to help relieve mild anxiety, stress, and support a healthy mood.

Hypericum perforatum in history

The specific extract used in Remotiv: Ze 117

Ze 117 is the exclusive extract of Hypericum perforatum used in Remotiv. The specific extract is developed according to strictly controlled production methods with careful consideration at every stage of growing, cultivation, extraction and production. 

This helps to ensure that each batch of Remotiv is consistent with the next and with the natural medicine tested in clinical research for relief of mild anxiety and stress. 

 

Maintaining quality consistency in the production of Ze 117 helps ensure consistency in the amount and composition of important active constituents from one batch to the next. 

 

In 2001, a study was conducted to test the Hyperforin content (a main compound of St John’s wort) of 8 different St John’s wort formulations. The results suggested that the available formulations at the time had varying and inconsistent amounts of Hyperforin from one batch to the next. While Remotiv was found to meet the batch-to-batch consistency criteria. 

 

Each Remotiv tablet contains:

Extract equivalent to dry Hypericum perforatum herb top flowering 1.375 g (harvested during flowering period) = 250 mg of St John’s wort extract  Ze 117

 

The therapeutic benefits of Ze 117 are based on multiple clinical studies involving over 1000 people.2-5 This research has shown that Ze 117  can help to support a healthy mood and  relieve:

  • Stress
  • Mild anxiety
  • Nervous tension
  • Restlessness
  • Irritability

Always read the label, use only as directed. If symptoms persist consult your healthcare professional.

The specific extract used in Remotiv: Ze 117

Research on how Ze 117 works

It is not fully understood how the Ze 117 extract of Hypericum perforatum works, however pre-clinical evidence suggests that it may have effects on three of the key neurotransmitters (serotonin, noradrenaline and dopamine) in the brain that are linked to mood and feelings of stress and nervous tension.  

The pre-clinical studies suggest that, Ze 117 has effects both on downregulation of receptors and re-uptake inhibition of serotonin, noradrenaline and dopamine.7,8

 

The studies also suggest that the therapeutic activity of Ze 117 is due to the overall effect of the entire Ze 117 extract which is stronger than the effect of single constituents of the extract. 

Research on how Ze 117 works

Ze 117 in clinical studies

Ze 117 has been researched in multiple clinical studies, including a study published in the British Medical Journal that was a one-year study that showed continued relief with good tolerability. 5  

Schrader 1998 2

162 patients with mood-related symptoms over 6 weeks*

Significant improvement

vs. placebo for:

  • Mood-related symptoms and showed:
    Good tolerability

*2 tablets of Ze 117 250mg

Schrader 2000 3

240 patients with mood-related symptoms over 6 weeks*

Positive results

for:

  • Improved mood-related symptoms
    Good tolerability

*2 tablets of Ze 117 250mg

 

Woelk 2000 4

324 patients with mood-related symptoms over 6 weeks*

Positive results

of:

  • Improved mood-related symptoms
    Improved feelings of mild anxiety
    Good tolerability

British Medical Journal

*2 tablets of Ze 117 250mg

Brattström 2009 5

440 patients with mood-related symptoms over 1 year

Improvement

of:

  • Mood-related symptoms and showed:
    Good tolerability

*2 tablets of Ze 117 250mg

SFI Health Difference

Ze 117 vs. St. John’s wort – The SFI Health difference

 

There may be several products on the market labeled as containing a particular ingredient – such as St. John’s wort. So what makes Ze 117 in Remotiv different?

 

Natural healthcare products can vary considerably depending on how they are produced. Ze 117 is a specific extract of St John’s wort made using highly controlled production methods with careful consideration at every stage of creation.

 

That means, you can be sure that the product you are getting contains the same specific extract demonstrated in clinical studies to help relieve stress, mild anxiety and support a healthy mood.  

Remotiv with Ze 117: A Summary

Consistent quality

Rigorous quality control processes and extensive testing to help ensure that the Ze 117 extract can provide the desired health outcomes demonstrated by clinical studies

Backed by years of research

To support a healthy mood and emotional balance

Helps relieve stress & mild anxiety

and eases feelings of nervous tension restlessness and irritability

Well tolerated and used worldwide

By millions of people for over 20 years.

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Our source to patient philosophy

We make sure our natural medicines are consistent.

Not only do the clinical studies on our products demonstrate real health outcomes, they demonstrate the results you can expect from the same products you see on shelf. It’s all part of our Source to Patient philosophy.

See the steps taken to make our products
References
  1. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Austin: American Botanical Council; 1998: 395-366
  2. Schrader E, et al. Human Psychopharmacology. 1998; 13:163-169.
  3. Schrader E. Int Clin Psychopharma. 2000; 15:61-68.
  4. Woelk H, et al. BMJ. 2000; 321:536-539.
  5. Brattström A. J Phymed. 2009; 16:277-283.
  6. Wurglics M, et al. J Am Pharm Assoc. 2001;41(4):560-566.
  7. Kientsch U, et al. Pharmacopsychiatry. 2001; 34 Suppl1: 56-60.
  8. Ruedeberg C, et al. Phytother Res. 2010; 24:249-251

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